[Nano-bme] NANO-BME Weekly Update

[nano-bme at gold.sdsmt.edu]

Greetings, All!

I hope you all had a lovely weekend and are looking forward to all that this final week in March has to offer! Seems we have lots going on as we embark on this last stretch of the semester, so be sure to stay focused, but to also give yourself permission to take breaks and do fun things in between all of the hustle and bustle of this busy time of year. Swing by the office any time for candy, a hot drink, and a fun fact of the day as needed. 😊 I just returned from a wonderful trip to Japan and hope to bring in a few snacks/treats from my travels sometime later this week.

If you didn’t already do so, here’s one last chance to celebrate National Disability Awareness Month, Women’s History Month, and National Reading Month by reading some interesting articles: Advancing Disability Inclusion in the Scientific Workforce<https://diversity.nih.gov/blog/2021-07-21-advancing-disability-inclusion-scientific-workforce> and Top 25 Women Leaders in Medical Devices of 2022<https://thehealthcaretechnologyreport.com/the-top-25-women-leaders-in-medical-devices-of-2022/>.

There are exciting opportunities for you and fun things happening this week and beyond. Check them out below!

Announcements & Reminders

  *   Follow us on our Department of Nanoscience & Biomedical Engineering Facebook<https://www.facebook.com/sdsmtnanobme> and Instagram<https://www.instagram.com/sdsmtnanobme/> accounts! We'd love to post anything exciting our students are up to. Internships, co-op's, new jobs, accomplishments, etc. Send any info you'd like to let us post to Dr. J. We also have Twitter<https://twitter.com/SdsmtB>, which is being run by Dr. Scott! Help us showcase all the great things we're doing!

  *   Be sure to meet with Dr. J sometime this semester to discuss your career goals & professional development opportunities (Book your appointment here<https://sdsmt.campus.eab.com/pal/NyfnNwlsuF>.)
  *   Volunteer Opportunities:
     *   Dr. J needs your help! We need volunteers for a couple of recruitment events coming up soon:
        *   Go To Mines (April 15th) – half day meeting with high school students. Please sign up by e-mailing Dr. J.
        *   The Spearfish Women in Science Conference May (10th)<volunteersignup.org/HRTX4> – All day event in Spearfish (can provide transportation if needed) meeting with middle school girls (Free lunch!) Please sign up using the link!
     *   StudyDakota is looking for tutors to serve K-12 students here in Rapid City! Getting involved with this program is a great way to give back to your community and pick up some volunteer hours along the way. Direct inquiries to studydakota at mines.sdsmt.edu<mailto:studydakota at mines.sdsmt.edu> and see attached flyer.
     *   MEDLIFE is a non-profit organization providing service-learning experiences in Peru, Ecuador, and Tanzania. They make trips over winter break, spring break, and during the summer to accommodate student schedules. See attached flyer or go here<https://my.medlifemovement.org/> for more details.
  *   Scholarship/Fellowship Opportunities:
     *   The SD Mines Chapter of the American Society of Microbiology will be presenting a workshop on applying for a NSF Graduate Research Fellowship Program (GRFP) on April 19th starting at 5:00PM in CBEC 2228. (Free Pizza!) If you are interested, please RSVP to Kelsey.gilcrease at sdsmt.edu<mailto:Kelsey.gilcrease at sdsmt.edu> by April 6th.
  *   Employment/Internship Opportunities:
     *   KBI Biopharma is actively recruiting students for their internship program! Learn more and apply by going here<https://www.kbibiopharma.com/careers-internships>.
     *   Indian Health Services is hiring biomedical equipment support specialists within the Office of Environmental Health and Engineering here in Rapid City. Learn more and apply for this job by going here<https://www.usajobs.gov/job/707973100>. Graduating seniors in BME are encouraged to apply.
        *   Additionally, 3 new positions were just posted for doing this same job in Pierre, SD. Here’s the link to learn more and apply for this position.<https://nam11.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.usajobs.gov%2Fjob%2F709604400&data=05%7C01%7CJohnica.morrow%40sdsmt.edu%7C9638f4ef4787401478e308db19da4ec8%7C867083e60b14435f9b4e8be26f01d84e%7C0%7C0%7C638132197649308498%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=fndMfOoc0EzUOXtLwXBS8KX9kvkNg1qq4cEXjZvcgPw%3D&reserved=0> If you have questions about these positions, Dr. J can put you in touch with one of our contacts at HIS, so don’t be afraid to ask!
     *   Genentech offers internships in biotechnology. Learn more by going here<https://careers.gene.com/us/en/internships>.
     *   Dakota Lions Sight & Health is hiring! Learn more about the positions open by going here<https://dakotasight.org/get-involved/employment-opportunities/> and see attached flyer.
     *   Check out GE’s list of internships by going here<https://jobs.gecareers.com/global/en/internships-co-ops>. More specifically, here are student opportunities through GE Healthcare<https://jobs.gecareers.com/healthcare/global/en/students-graduates>.
  *   Other Professional Development Opportunities:
     *   Are you part of an underrepresented group applying to medical school in the next cycle? Check out this free virtual conference on Saturday, April 22nd from 9:00AM-4:30PM MST hosted by Harvard Medical School called Empower: A Symposium on Underrepresented Voices in Medicine<https://snma.hms.harvard.edu/empower_conference>. The conference will feature panels and discussions with current Harvard Medical School students, alumni, and affiliated physicians of similar identities. Topics include, but are not limited to: The MCAT, Crafting the Personal Statement and Secondaries, Keeping it Real with HMS Students and much more! As registration is limited, individuals interested in attending the conference must pre-register using this link<https://bit.ly/2023Empower>.
     *   Looking for supplemental clinical shadowing opportunities? Check out HEAL for shadowing 101 courses that are free and happening every Wednesday night. (*Note that this should not be your only shadowing experience, but it is a great way to gain some additional shadowing and learn some new things. 😊) Learn more and sign up by going here<https://www.clinicalshadowing.com/>.
     *   Want to earn your CNA and start working with patients to gain direct patient care experiences? Check out the Nursing Assistant Program that is part of the Rural Health Works Nursing Initiative<https://www.westriversdahec.org/rural-health-works/> run by the WRAHEC to learn how they will cover 100% of the tuition for your 8-week course through Monument Health. (This is a great way to gain clinical experiences, which are required for admission into professional programs in healthcare, such as med school, PA school, etc.)
     *   If you are interested in studying abroad, be sure to swing by and chat with Suzi Aadland and Beth Riley in the Ivanhoe International Center<https://www.sdsmt.edu/Campus-Life/Ivanhoe-International-Center/>. They can help you plan an amazing learning journey! 😊
        *   Also, did you know that South Dakota Mines offers both a minor and a certificate in Global Engineering & Science? Learn more about these by going here<https://www.sdsmt.edu/Academics/Study-Abroad/Global-Academic-Focus/>.
           *   If you are interested download this checklist for the minor<https://www.sdsmt.edu/Academics/Study-Abroad/Docs/Global-Engineering---Science-Minor-Checklist/> and this checklist for the certificate<https://www.sdsmt.edu/Academics/Study-Abroad/Docs/Global-Engineering---Science-Certificate-Checklist/>.
     *   Are you a member of a professional organization, such as the Biophysical Society<https://www.biophysics.org/>, the Biomedical Engineering Society<https://www.bmes.org/>, or the Society for Biomaterials<https://biomaterials.org/>? If not, you should be! Click to learn more about those organizations and ask Dr. J if you want to know more about why these organizations are important.
        *   If you are in our campus chapter of BMES, but not a member of the national organization, you can change that for only $15! (One of the cheapest membership dues for a national society that I’ve ever seen.) Here’s some information about the benefits of becoming a national member<https://www.bmes.org/content.asp?admin=Y&contentid=578>.
     *   Spring 2023 Semester Schedule for future BMES Meetings:

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This Week’s Events/Reminders:
Monday, March 27th:

  *   Deadline for registering for the SWE Dinner later this week! (See attached flyer.)
  *   Deadline for speaking with the Ivanhoe International Center about applying to study abroad in Norway at OsloMet.
  *   6:30PM – The Future Health Science Professionals (FHSP) is having a meeting in CBEC 3304 to talk about the needs of pre-health students on campus. Points raised at this discussion will be carried forward to the newly resurrected Pre-Health Advisory Committee, formed to help support pre-health students across campus. If you are interested in a career as a healthcare professional, I highly encourage you to attend this meeting and voice your concerns/needs.
Tuesday, March 28th:

  *   The AAMC is hosting the 2023 Virtual Medical School Fair on March 28th-29th. Attendees who register will be given 15% off of a MSAR subscription and the fair will include live information sessions and chats with medical school students and representatives for a wide range of programs. Learn more and register for this free event by going here<https://aamcmedschoolfair.vfairs.com/?utm_source=sfmc&utm_medium=email&utm_campaign=VMSF&utm_content=marchfair2023>.
Wednesday, March 29th:

  *   The AAMC is hosting the 2023 Virtual Medical School Fair on March 28th-29th. Attendees who register will be given 15% off of a MSAR subscription and the fair will include live information sessions and chats with medical school students and representatives for a wide range of programs. Learn more and register for this free event by going here<https://aamcmedschoolfair.vfairs.com/?utm_source=sfmc&utm_medium=email&utm_campaign=VMSF&utm_content=marchfair2023>.
  *   9:00AM-3:00PM – Get in the Game event for getting on the Be the Match Registry for blood stem cell transplants. Swing by the Devereaux Library to get your cheek swabbed and join the Be the Match Registry. (You can also volunteer to help with this event. See attached poster.)
  *   10:30AM MST – VCOM is hosting a Virtual Physician Experience that will end with an admissions Q&A. Register by going here<https://forms.office.com/Pages/ResponsePage.aspx?id=ex-PmxOwcUSoxJmhXsyLHLZFy792TjpJq5YDLhfLtYxUQThBMFRHRVlIQlNQR0I0MkNRMDRDVTNITC4u>.
Thursday, March 30th:

  *   Deadline for applying to study abroad in Colombia at Pontificia Universidad Javeriana.
  *   10:30AM MST – VCOM is hosting a virtual Sports Medicine Event to allow prospective students to meet with VCOM’s Sports Medicine Students and to hear their stories. Register by going here<https://forms.office.com/Pages/ResponsePage.aspx?id=ex-PmxOwcUSoxJmhXsyLHLZFy792TjpJq5YDLhfLtYxUM0lFWTRURlNDNkVBTTUyU0ZINFBaS1hGMi4u>.
  *   4:00PM – NANO-BME Seminar (EEP 253 and via Zoom) – See attached pdf for topics!
  *   5:00PM – SWE Dinner in the Alumni Center Ballroom (Free for students! Register by March 27th.)
  *   5:00PM MST – Careers in Pharmacy Live Virtual Panel. Learn more and register by going here<https://bit.ly/HPWSp2023>.
Friday, March 31st:

  *   Deadline for applying for the Baden-Wurttemberg Scholarships for study abroad in Germany at Aalen University.
  *   Deadline for speaking with the Ivanhoe International Center about applying to study abroad in Norway at University of Southeast Norway.
  *   Deadline for applying to the fall study abroad program at the University College London. More information here<https://www.ucl.ac.uk/prospective-students/study-abroad-at-ucl/>.
  *   7:30AM-8:30AM MST - Monument Health Virtual Grand Rounds! This week’s topic has not yet been announced, but will be shared in a separate e-mail when it is. You will be able to join the virtual session via WebEx using this link<https://monumenthealth.webex.com/monumenthealth/j.php?MTID=me60ee485885ca07d5490f7e0b37013d6>.

This Weekend:

  *   11AM-2PM – Cultural Expo on Saturday, April 1st! Food and entertainment in the Surbeck Ballroom.
  *   Youth and Family Services is looking for volunteers to help with their annual Kids Fair on Saturday, April 1st and Sunday, April 2nd. Volunteers will help run activities for kids, monitor entrances, etc. Sign up by going here<https://signup.com/client/invitation2/secure/9270354356684940110/false#/invitation> or contact Connie Olson for any questions via e-mail (COlson at youthandfamilyservices.org<mailto:COlson at youthandfamilyservices.org>) or phone (605-342-4195).

Other Upcoming Events:

  *   2:00PM – Shayne Quinn (NANO PhD student) is defending his dissertation on April 6th in EEP 255. Be sure to swing by in person or tune in via Zoom: https://sdsmt.zoom.us/j/94052609703
     *   Abstract: Macropinocytosis is the process of cell drinking in which plasma membrane rufflesextend, curve, and return to the plasma membrane surface to form large intracellularorganelles called a macropinosome. This complex process can be carefully understoodthrough the constant advancements in multidimensional fluorescence microscopy,specifically lattice light sheet (LLS), however there follows a demand for datavisualization tools capable of displaying the complex cellular processes. While LLSmicroscopes produce stunning movies of cellular activity with high spatial and temporalresolution, they have been slow to be widely adopted. Experiments on this instrumentrequire understanding fluorescence microscopy, cell biology, data management,computer science, and most importantly presenting 5 dimensions of data (x, y, z, t, λ) intoa scientifically accurate 2-dimensional manuscript. The first objective focused on how todevelop an experiment for LLS microscopy as many traditional experiments requireunique preparations and considerations. Experimental development was followed by adiscussion of the limitations, and applications of the different visualization tools thatwere developed including volumetric intensities, orthogonal planes, isosurfaces, andmesh overlays. Furthermore, a non-programing based step-by-step protocol was createdfor using ChimeraX for LLS data visualization. These techniques were developed tounderstand macropinocytosis, a process where actin-rich plasma membrane ruffles forminto large intracellular organelles, in a phosphatidylinositol 3-kinase (PI3K)-coordinatedmanner. The visualization tools were used to show that macropinosomes were formedthrough multiple ruffling morphologies and that the majority formed through collisions ofadjacent PI3K-rich ruffles. Furthermore, we showed that PI3K activity begins earlythroughout the ruffle volume and continued to increase until peak activity concentrated atthe base of the ruffle after macropinosome closure. Additionally, through pharmacologicinhibition of PI3K activity we showed there was little effect on the rate and morphologyof membrane ruffling. Finally, we demonstrated that early production of 3′-phosphoinositides within ruffles plays a minor role in regulating their morphologyhowever, 3′-phosphoinositides are critical for sealing ruffles into macropinosomes.Through the development and application of LLS visualization techniques these dataindicate that local PI3K activity is amplified in ruffles and serves as a primingmechanism for closure and sealing of ruffles into macropinosomes.

On the Replay:

  *   Did you miss the Ivanhoe International Center’s Education Abroad Info Session? Check out the recording here<https://sdsmt.hosted.panopto.com/Panopto/Pages/Sessions/List.aspx?folderID=24ebcc88-f819-4a27-b8f1-af97014d21f8>.
  *   Need to know how to apply for a passport? Check out these Passport 101<https://sdsmt.zoom.us/rec/play/GLGB0x1UQnMBAYMZzT77dkGon9Jp0Gw4q2QSC3g68xTHC08tf3Cb46hCenWpq_OLpEYhqafnxkjO2DRu.CBcU5-tVQLTDcxXZ?continueMode=true> and Passport 201<https://sdsmt.zoom.us/rec/play/MIEXtQCvt3B1PnVTc01pz2u_rm4FuZkphRlWnFDsof0WxabVEiQ8pt2-U9eDxFNPm4bVntvkdmmAub2w.CIHG47ER91T2SlnC?continueMode=true> videos.
  *   SHPEPconnect webinar: Diversity Session 1: Dispelling the Myths of Admissions<https://www.youtube.com/watch?v=QQixHebPtgI&ab_channel=SHPEPconnect>

Feel free to reach out if you have any questions or would like to know more about opportunities, events, or activities related to our department!

Have a wonderful week,

~Dr. J

Dr. Johnica J. Winter, (she/her)
NANO-BME Program Coordinator
Nanoscience & Biomedical Engineering
South Dakota Mines
501 E. Saint Joseph St., Rapid City, SD 57701
605.394.1911 | Schedule an Appointment<https://sdsmt.campus.eab.com/pal/NyfnNwlsuF>
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